WEBVTT

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Bio Beats. Big picture first:

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every map of you is a layer on one big idea.

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Fifty-eight, Francis Crick laid the rule down plain:

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DNA to RNA to protein, one-way train.

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Ninety: the Genome Project, a thirteen-year run,

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three billion letters, and it still wasn't done.

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Twenty-twenty-two, T2T sealed the gaps,

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then the pangenome put more people on the map.

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Only one or two percent spells out a protein:

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twenty thousand genes, and the switches in between.

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From the code to the cell, we're mapping you,

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DNA, RNA, protein, through and through.

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Each map's a layer, each layer's a view,

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stack all the layers, and the map is you.

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Your liver and your brain hold the same exact book,

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but they read different pages. ENCODE took a look,

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mapped the switches on the strand, two million strong:

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the promoters and enhancers saying which gene's on.

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GTEx checked the volume, tissue after tissue:

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same gene: loud in liver, in the brain a whisper.

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Human Cell Atlas reads it one cell at a time,

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trillions of cells, and the goal's to name each kind.

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HuBMAP pins each cell to the spot where it sits,

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'cause a cell without a zip code's just a name on a list.

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From the code to the cell, we're mapping you,

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DNA, RNA, protein, through and through.

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Each map's a layer, each layer's a view,

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stack all the layers, and the map is you.

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Protein Atlas out of Sweden, since two-thousand-three:

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antibodies light the rooms where the proteins like to be.

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Microbiome Project mapped the tenants in your gut:

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not ten bugs per cell, more like one for one, but

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their genes outnumber yours a hundred times or more.

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Connectome: half a rice grain, mapped to the core:

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a hundred fifty million synapses. It's insane.

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Now times that by a million for the whole brain.

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From the code to the cell, we're mapping you,

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DNA, RNA, protein, through and through.

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Each map's a layer, each layer's a view,

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stack all the layers, and the map is you.

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Big picture first, then layer on the view,

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link every map, 'cause the map is you.

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Class dismissed.